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Lysosomal acid lipase deficiency an under-recognized cause of dyslipidaemia and liver dysfunction
SURMOUNT-1 demonstrated average weight loss of approximately 21% at the highest dose
Variability in glycaemic control and obesity are associated with increased TSH levels, which normalise after optimisation of glycaemic control
25, 38 As aberrations in the TP53 gene and t(4:14) translocations are seen in 15% of patients 49 and correlated with short progression-free survival and resistance to alkylating agents at relapse, 50 the ability of BSO to sensitize MM cells with this phenotype suggests that BSO+L-PAM may have clinical activity in the most aggressive forms of MM
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